Seroatlas · Human Serome Atlas

IGLV3-25

Immunoglobulin lambda variable 3-25

Also known as: LV325_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01717
Gene
IGLV3-25
Ensembl
ENSG00000211659
Chromosome
22
Canonical length
112 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>P01717|IGLV3-25
     1  MAWIPLLLPL LTLCTGSEAS YELTQPPSVS VSPGQTARIT CSGDALPKQY AYWYQQKPGQ
    61  APVLVIYKDS ERPSGIPERF SGSSSGTTVT LTISGVQAED EADYYCQSAD SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV3-25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
2,275 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 2,275 nTPM
  • lymph node: 960 nTPM
  • stomach: 955 nTPM
  • lung: 822 nTPM
  • colon: 791 nTPM
  • urinary bladder: 732 nTPM

Single-cell type

  • plasma cells: 24 nCPM
  • gastric chief cells: 12 nCPM
  • parietal cells: 5.3 nCPM
  • mucous neck cells: 2.4 nCPM
  • foveolar cells: 2.3 nCPM
  • b-cells: 1.1 nCPM

Immune cell

  • naive B-cell: 799 nTPM
  • memory B-cell: 548 nTPM
  • total PBMC: 77 nTPM
  • neutrophil: 15 nTPM
  • basophil: 0.8 nTPM
  • gdT-cell: 0.7 nTPM

Brain region

  • medulla oblongata: 3.4 nTPM
  • choroid plexus: 2.4 nTPM
  • cerebral cortex: 1.1 nTPM
  • pons: 0.9 nTPM
  • white matter: 0.8 nTPM
  • thalamus: 0.7 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV3-25 as an antibody target. Whether an autoantibody or antibody against IGLV3-25 could matter depends on whether native IGLV3-25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV3-25 is annotated at the cell surface, where native IGLV3-25 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV3-25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV3-25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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