Seroatlas · Human Serome Atlas

IGLV3-22

Immunoglobulin lambda variable 3-22

Also known as: LV322_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6J6
Gene
IGLV3-22
Ensembl
ENSG00000211661
Chromosome
22
Canonical length
115 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to act upstream of or within apoptotic signaling pathway; negative regulation of stem cell proliferation; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and extracellular space. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A075B6J6|IGLV3-22
     1  MAWATLLLPL LNLYTGSVAS YELTQLPSVS VSPGQTARIT CSGDVLGENY ADWYQQKPGQ
    61  APELVIYEDS ERYPGIPERF SGSTSGNTTT LTISRVLTED EADYYCLSGD EDNPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV3-22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 8.8 nTPM
  • tonsil: 4.9 nTPM
  • lymph node: 3.9 nTPM
  • breast: 2.4 nTPM
  • bone marrow: 1.4 nTPM
  • colon: 1.4 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • naive B-cell: 7.8 nTPM
  • memory B-cell: 6.6 nTPM
  • total PBMC: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • pons: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV3-22 as an antibody target. Whether an autoantibody or antibody against IGLV3-22 could matter depends on whether native IGLV3-22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV3-22 is annotated at the cell surface, where native IGLV3-22 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV3-22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV3-22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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