Seroatlas · Human Serome Atlas

IGLV3-21

Immunoglobulin lambda variable 3-21

Also known as: LV321_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P80748
Gene
IGLV3-21
Ensembl
ENSG00000211662
Chromosome
22
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P80748|IGLV3-21
     1  MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS VHWYQQKPGQ
    61  APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVEAGD EADYYCQVWD SSSDHPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV3-21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,697 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,697 nTPM
  • urinary bladder: 726 nTPM
  • stomach: 474 nTPM
  • spleen: 398 nTPM
  • colon: 335 nTPM
  • duodenum: 330 nTPM

Single-cell type

  • plasma cells: 84 nCPM
  • gastric chief cells: 9.8 nCPM
  • parietal cells: 7.1 nCPM
  • late spermatids: 5.8 nCPM
  • late primary spermatocytes: 3.8 nCPM
  • early spermatids: 3.5 nCPM

Immune cell

  • memory B-cell: 433 nTPM
  • naive B-cell: 226 nTPM
  • total PBMC: 37 nTPM
  • neutrophil: 0.9 nTPM
  • myeloid DC: 0.3 nTPM
  • basophil: 0.2 nTPM

Brain region

  • choroid plexus: 2.9 nTPM
  • cerebral cortex: 2.7 nTPM
  • white matter: 2.3 nTPM
  • medulla oblongata: 1.6 nTPM
  • pons: 0.6 nTPM
  • amygdala: 0.5 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV3-21 as an antibody target. Whether an autoantibody or antibody against IGLV3-21 could matter depends on whether native IGLV3-21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV3-21 is annotated at the cell surface, where native IGLV3-21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV3-21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV3-21. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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