IGLV3-12
Immunoglobulin lambda variable 3-12
Also known as: LV312_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6K2
- Gene
- IGLV3-12
- Ensembl
- ENSG00000211667
- Chromosome
- 22
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A075B6K2|IGLV3-12
1 MAWTPLLLSL LAHCTGSATS YELTQPHSVS VATAQMARIT CGGNNIGSKA VHWYQQKPGQ
61 DPVLVIYSDS NRPSGIPERF SGSNPGNTAT LTISRIEAGD EADYYCQVWD SSSDHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV3-12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 28 nTPM
- lymph node: 14 nTPM
- stomach: 7.7 nTPM
- colon: 6.8 nTPM
- duodenum: 5.2 nTPM
- salivary gland: 4.8 nTPM
Single-cell type
- plasma cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- memory B-cell: 9.2 nTPM
- naive B-cell: 6.8 nTPM
- NK-cell: 5.7 nTPM
- gdT-cell: 4.3 nTPM
- memory CD8 T-cell: 4 nTPM
- total PBMC: 1.3 nTPM
Brain region
- choroid plexus: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
- medulla oblongata: 0.2 nTPM
- white matter: 0.2 nTPM
- amygdala: 0.1 nTPM
- hypothalamus: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV3-12 as an antibody target. Whether an autoantibody or antibody against IGLV3-12 could matter depends on whether native IGLV3-12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV3-12 is annotated at the cell surface, where native IGLV3-12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV3-12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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