IGLV3-10
Immunoglobulin lambda variable 3-10
Also known as: LV310_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6K4
- Gene
- IGLV3-10
- Ensembl
- ENSG00000211669
- Chromosome
- 22
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A075B6K4|IGLV3-10
1 MAWTPLLLPL LTFCTVSEAS YELTQPPSVS VSPGQTARIT CSGDALPKKY AYWYQQKSGQ
61 APVLVIYEDS KRPSGIPERF SGSSSGTMAT LTISGAQVED EADYYCYSTD SSGNHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV3-10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 659 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 659 nTPM
- rectum: 296 nTPM
- colon: 287 nTPM
- stomach: 272 nTPM
- lymph node: 216 nTPM
- spleen: 212 nTPM
Single-cell type
- plasma cells: 18 nCPM
- gastric chief cells: 6.6 nCPM
- cholangiocytes: 1.3 nCPM
- mast cells: 0.6 nCPM
- b-cells: 0.4 nCPM
- mesothelial cells: 0.3 nCPM
Immune cell
- memory B-cell: 551 nTPM
- naive B-cell: 317 nTPM
- total PBMC: 43 nTPM
- basophil: 0.5 nTPM
- classical monocyte: 0.3 nTPM
- eosinophil: 0.3 nTPM
Brain region
- medulla oblongata: 3.4 nTPM
- cerebral cortex: 1.2 nTPM
- choroid plexus: 1 nTPM
- pons: 0.9 nTPM
- amygdala: 0.7 nTPM
- basal ganglia: 0.5 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV3-10 as an antibody target. Whether an autoantibody or antibody against IGLV3-10 could matter depends on whether native IGLV3-10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV3-10 is annotated at the cell surface, where native IGLV3-10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV3-10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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