Seroatlas · Human Serome Atlas

IGLV3-1

Immunoglobulin lambda variable 3-1

Also known as: LV301_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01715
Gene
IGLV3-1
Ensembl
ENSG00000211673
Chromosome
22
Canonical length
115 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P01715|IGLV3-1
     1  MAWIPLFLGV LAYCTGSVAS YELTQPPSVS VSPGQTASIT CSGDKLGDKY ACWYQQKPGQ
    61  SPVLVIYQDS KRPSGIPERF SGSNSGNTAT LTISGTQAMD EADYYCQAWD SSTAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV3-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
3,105 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 3,105 nTPM
  • stomach: 1,372 nTPM
  • colon: 1,153 nTPM
  • lymph node: 1,045 nTPM
  • rectum: 640 nTPM
  • urinary bladder: 638 nTPM

Single-cell type

  • plasma cells: 302 nCPM
  • parietal cells: 12 nCPM
  • gastric chief cells: 8.7 nCPM
  • foveolar cells: 4.3 nCPM
  • mucous neck cells: 2 nCPM
  • b-cells: 1.3 nCPM

Immune cell

  • naive B-cell: 1,046 nTPM
  • memory B-cell: 784 nTPM
  • total PBMC: 52 nTPM
  • myeloid DC: 1.2 nTPM
  • classical monocyte: 1.1 nTPM
  • non-classical monocyte: 0.8 nTPM

Brain region

  • pons: 2.7 nTPM
  • medulla oblongata: 1.8 nTPM
  • cerebral cortex: 1.6 nTPM
  • choroid plexus: 1.6 nTPM
  • white matter: 1.4 nTPM
  • hypothalamus: 0.6 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV3-1 as an antibody target. Whether an autoantibody or antibody against IGLV3-1 could matter depends on whether native IGLV3-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV3-1 is annotated at the cell surface, where native IGLV3-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV3-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV3-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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