Seroatlas · Human Serome Atlas

IGLV2-8

Immunoglobulin lambda variable 2-8

Also known as: LV208_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01709
Gene
IGLV2-8
Ensembl
ENSG00000278196
Chromosome
22
Canonical length
118 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P01709|IGLV2-8
     1  MAWALLLLTL LTQGTGSWAQ SALTQPPSAS GSPGQSVTIS CTGTSSDVGG YNYVSWYQQH
    61  PGKAPKLMIY EVSKRPSGVP DRFSGSKSGN TASLTVSGLQ AEDEADYYCS SYAGSNNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV2-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,068 nTPM

Expression across tissuesHPA

Tissue

  • colon: 1,068 nTPM
  • tonsil: 947 nTPM
  • duodenum: 917 nTPM
  • small intestine: 425 nTPM
  • spleen: 412 nTPM
  • stomach: 408 nTPM

Single-cell type

  • plasma cells: 88 nCPM
  • gastric chief cells: 14 nCPM
  • parietal cells: 5.3 nCPM
  • platelets: 2.8 nCPM
  • mucous neck cells: 2.4 nCPM
  • foveolar cells: 2.1 nCPM

Immune cell

  • naive B-cell: 2,116 nTPM
  • memory B-cell: 1,445 nTPM
  • total PBMC: 174 nTPM
  • neutrophil: 14 nTPM
  • classical monocyte: 2.4 nTPM
  • gdT-cell: 2.1 nTPM

Brain region

  • cerebral cortex: 3.7 nTPM
  • choroid plexus: 2.6 nTPM
  • amygdala: 1.6 nTPM
  • white matter: 1.2 nTPM
  • medulla oblongata: 1 nTPM
  • spinal cord: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGLV2-8.

Disease | ImmuneIEDB

Conditions an epitope on IGLV2-8 was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV2-8 as an antibody target. Whether an autoantibody or antibody against IGLV2-8 could matter depends on whether native IGLV2-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV2-8 is annotated at the cell surface, where native IGLV2-8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV2-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV2-8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...