Seroatlas · Human Serome Atlas

IGLV2-23

Immunoglobulin lambda variable 2-23

Also known as: LV223_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01705
Gene
IGLV2-23
Ensembl
ENSG00000211660
Chromosome
22
Canonical length
113 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>P01705|IGLV2-23
     1  MAWALLLLTL LTQDTGSWAQ SALTQPASVS GSPGQSITIS CTGTSSDVGS YNLVSWYQQH
    61  PGKAPKLMIY EGSKRPSGVS NRFSGSKSGN TASLTISGLQ AEDEADYYCC SYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV2-23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,495 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,495 nTPM
  • duodenum: 649 nTPM
  • stomach: 632 nTPM
  • colon: 593 nTPM
  • lymph node: 584 nTPM
  • spleen: 502 nTPM

Single-cell type

  • plasma cells: 62 nCPM
  • parietal cells: 8.8 nCPM
  • gastric chief cells: 8.7 nCPM
  • megakaryocytes: 6.2 nCPM
  • mucous neck cells: 4.4 nCPM
  • foveolar cells: 2.9 nCPM

Immune cell

  • naive B-cell: 2,618 nTPM
  • memory B-cell: 2,082 nTPM
  • total PBMC: 232 nTPM
  • neutrophil: 6.3 nTPM
  • classical monocyte: 3.1 nTPM
  • myeloid DC: 2.6 nTPM

Brain region

  • cerebral cortex: 1.9 nTPM
  • medulla oblongata: 1.8 nTPM
  • amygdala: 1.2 nTPM
  • choroid plexus: 1.1 nTPM
  • pons: 0.7 nTPM
  • basal ganglia: 0.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV2-23 as an antibody target. Whether an autoantibody or antibody against IGLV2-23 could matter depends on whether native IGLV2-23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV2-23 is annotated at the cell surface, where native IGLV2-23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV2-23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV2-23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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