IGLV2-18
Immunoglobulin lambda variable 2-18
Also known as: LV218_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6J9
- Gene
- IGLV2-18
- Ensembl
- ENSG00000211664
- Chromosome
- 22
- Canonical length
- 118 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>A0A075B6J9|IGLV2-18
1 MAWALLLLTL LTQGTGSWAQ SALTQPPSVS GSPGQSVTIS CTGTSSDVGS YNRVSWYQQP
61 PGTAPKLMIY EVSNRPSGVP DRFSGSKSGN TASLTISGLQ AEDEADYYCS LYTSSSTFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV2-18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 253 nTPM
Expression across tissuesHPA
Tissue
- colon: 253 nTPM
- duodenum: 247 nTPM
- tonsil: 209 nTPM
- small intestine: 141 nTPM
- rectum: 129 nTPM
- spleen: 95 nTPM
Single-cell type
- plasma cells: 7.4 nCPM
- parietal cells: 1.8 nCPM
- late spermatids: 0.7 nCPM
- foveolar cells: 0.6 nCPM
- b-cells: 0.1 nCPM
- vascular endothelial cells: 0.1 nCPM
Immune cell
- memory B-cell: 323 nTPM
- naive B-cell: 128 nTPM
- total PBMC: 70 nTPM
- NK-cell: 5 nTPM
- classical monocyte: 1.8 nTPM
- gdT-cell: 1.7 nTPM
Brain region
- pons: 0.9 nTPM
- medulla oblongata: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- choroid plexus: 0.1 nTPM
- spinal cord: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV2-18 as an antibody target. Whether an autoantibody or antibody against IGLV2-18 could matter depends on whether native IGLV2-18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV2-18 is annotated at the cell surface, where native IGLV2-18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV2-18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...