IGLV2-14
Immunoglobulin lambda variable 2-14
Also known as: LV214_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01704
- Gene
- IGLV2-14
- Ensembl
- ENSG00000211666
- Chromosome
- 22
- Canonical length
- 120 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
120 residues, UniProt reviewed canonical sequence.
>P01704|IGLV2-14
1 MAWALLLLTL LTQGTGSWAQ SALTQPASVS GSPGQSITIS CTGTSSDVGG YNYVSWYQQH
61 PGKAPKLMIY EVSNRPSGVS NRFSGSKSGN TASLTISGLQ AEDEADYYCS SYTSSSTLHSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV2-14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 5,019 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 5,019 nTPM
- lymph node: 3,104 nTPM
- colon: 2,450 nTPM
- stomach: 2,378 nTPM
- duodenum: 2,319 nTPM
- spleen: 1,466 nTPM
Single-cell type
- plasma cells: 180 nCPM
- gastric chief cells: 27 nCPM
- erythrocytes: 22 nCPM
- foveolar cells: 7.1 nCPM
- parietal cells: 5.3 nCPM
- mucous neck cells: 3.9 nCPM
Immune cell
- memory B-cell: 3,672 nTPM
- naive B-cell: 2,675 nTPM
- total PBMC: 453 nTPM
- NK-cell: 63 nTPM
- memory CD8 T-cell: 54 nTPM
- gdT-cell: 47 nTPM
Brain region
- cerebral cortex: 8.3 nTPM
- choroid plexus: 5.8 nTPM
- white matter: 2.7 nTPM
- medulla oblongata: 2.3 nTPM
- basal ganglia: 2.1 nTPM
- spinal cord: 1.7 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV2-14 as an antibody target. Whether an autoantibody or antibody against IGLV2-14 could matter depends on whether native IGLV2-14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV2-14 is annotated at the cell surface, where native IGLV2-14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV2-14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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