IGLV11-55
Probable non-functional immunoglobulin lambda variable 11-55
Also known as: LVK55_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6I3
- Gene
- IGLV11-55
- Ensembl
- ENSG00000211641
- Chromosome
- 22
- Canonical length
- 123 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>A0A075B6I3|IGLV11-55
1 MALTPLLLLL LSHCTGSLSR PVLTQPPSLS ASPGATARLP CTLSSDLSVG GKNMFWYQQK
61 LGSSPRLFLY HYSDSDKQLG PGVPSRVSGS KETSSNTAFL LISGLQPEDE ADYYCQVYES
121 SANLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV11-55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 1 nTPM
- rectum: 0.8 nTPM
- duodenum: 0.6 nTPM
- small intestine: 0.5 nTPM
- colon: 0.4 nTPM
- lymph node: 0.4 nTPM
Single-cell type
- late spermatids: 7.4 nCPM
- early spermatids: 0.9 nCPM
- plasma cells: 0.6 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- MAIT T-cell: 0.6 nTPM
- memory B-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 0.9 nTPM
- white matter: 0.5 nTPM
- basal ganglia: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
- pons: 0.1 nTPM
- amygdala: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV11-55 as an antibody target. Whether an autoantibody or antibody against IGLV11-55 could matter depends on whether native IGLV11-55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV11-55 is annotated at the cell surface, where native IGLV11-55 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV11-55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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