Seroatlas · Human Serome Atlas

IGLV10-54

Immunoglobulin lambda variable 10-54

Also known as: LVX54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6I4
Gene
IGLV10-54
Ensembl
ENSG00000211642
Chromosome
22
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A075B6I4|IGLV10-54
     1  MPWALLLLTL LTHSAVSVVQ AGLTQPPSVS KGLRQTATLT CTGNSNIVGN QGAAWLQQHQ
    61  GHPPKLLSYR NNNRPSGISE RFSASRSGNT ASLTITGLQP EDEADYYCSA LDSSLSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV10-54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
307 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 307 nTPM
  • colon: 303 nTPM
  • duodenum: 276 nTPM
  • salivary gland: 239 nTPM
  • stomach: 183 nTPM
  • rectum: 145 nTPM

Single-cell type

  • plasma cells: 14 nCPM
  • b-cells: 2.3 nCPM
  • proximal tubule cells: 1.9 nCPM
  • distal convoluted tubule cells: 1.4 nCPM
  • renal collecting duct intercalated cells: 1.4 nCPM
  • renal connecting tubule cells: 1.3 nCPM

Immune cell

  • memory B-cell: 59 nTPM
  • naive B-cell: 35 nTPM
  • total PBMC: 7.7 nTPM
  • MAIT T-cell: 1.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • medulla oblongata: 2.6 nTPM
  • cerebral cortex: 2 nTPM
  • choroid plexus: 1.4 nTPM
  • white matter: 1 nTPM
  • basal ganglia: 0.4 nTPM
  • hypothalamus: 0.3 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV10-54 as an antibody target. Whether an autoantibody or antibody against IGLV10-54 could matter depends on whether native IGLV10-54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV10-54 is annotated at the cell surface, where native IGLV10-54 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV10-54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV10-54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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