IGLV1-50
Probable non-functional immunoglobulin lambda variable 1-50
Also known as: LV150_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6I6
- Gene
- IGLV1-50
- Ensembl
- ENSG00000211645
- Chromosome
- 22
- Canonical length
- 118 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>A0A075B6I6|IGLV1-50
1 MAWSSLLLTL LAHCTGSWAQ SVLTQPPSVS GAPGQRVTIS CTGSSSNIGA GYVVHWYQQL
61 PGTAPKLLIY GNSNRPSGVP DQFSGSKSGT SASLAITGLQ SEDEADYYCK AWDNSLNALocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV1-50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- stomach: 19 nTPM
- duodenum: 15 nTPM
- tonsil: 14 nTPM
- small intestine: 8.8 nTPM
- urinary bladder: 8.8 nTPM
- breast: 6.2 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 11 nTPM
- naive B-cell: 2.9 nTPM
- total PBMC: 0.9 nTPM
- gdT-cell: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebral cortex: 7.6 nTPM
- cerebellum: 7.5 nTPM
- white matter: 5.8 nTPM
- pons: 5.2 nTPM
- hippocampal formation: 4.3 nTPM
- basal ganglia: 3.9 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV1-50 as an antibody target. Whether an autoantibody or antibody against IGLV1-50 could matter depends on whether native IGLV1-50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV1-50 is annotated at the cell surface, where native IGLV1-50 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV1-50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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