IGLV1-47
Immunoglobulin lambda variable 1-47
Also known as: LV147_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01700
- Gene
- IGLV1-47
- Ensembl
- ENSG00000211648
- Chromosome
- 22
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01700|IGLV1-47
1 MAGFPLLLTL LTHCAGSWAQ SVLTQPPSAS GTPGQRVTIS CSGSSSNIGS NYVYWYQQLP
61 GTAPKLLIYS NNQRPSGVPD RFSGSKSGTS ASLAISGLRS EDEADYYCAA WDDSLSGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV1-47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 1,684 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 1,684 nTPM
- spleen: 734 nTPM
- duodenum: 662 nTPM
- colon: 660 nTPM
- lymph node: 646 nTPM
- stomach: 588 nTPM
Single-cell type
- plasma cells: 89 nCPM
- gastric chief cells: 9.8 nCPM
- foveolar cells: 4.5 nCPM
- parietal cells: 3.5 nCPM
- conjunctival goblet cells: 1 nCPM
- b-cells: 0.9 nCPM
Immune cell
- memory B-cell: 1,525 nTPM
- naive B-cell: 825 nTPM
- total PBMC: 160 nTPM
- plasmacytoid DC: 1.8 nTPM
- classical monocyte: 1.2 nTPM
- myeloid DC: 1 nTPM
Brain region
- medulla oblongata: 4.2 nTPM
- white matter: 4.2 nTPM
- cerebral cortex: 3.1 nTPM
- pons: 1.7 nTPM
- choroid plexus: 1.1 nTPM
- amygdala: 0.9 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV1-47 as an antibody target. Whether an autoantibody or antibody against IGLV1-47 could matter depends on whether native IGLV1-47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV1-47 is annotated at the cell surface, where native IGLV1-47 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV1-47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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