Seroatlas · Human Serome Atlas

IGLV1-40

Immunoglobulin lambda variable 1-40

Also known as: LV140_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01703
Gene
IGLV1-40
Ensembl
ENSG00000211653
Chromosome
22
Canonical length
118 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P01703|IGLV1-40
     1  MAWSPLLLTL LAHCTGSWAQ SVLTQPPSVS GAPGQRVTIS CTGSSSNIGA GYDVHWYQQL
    61  PGTAPKLLIY GNSNRPSGVP DRFSGSKSGT SASLAITGLQ AEDEADYYCQ SYDSSLSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV1-40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,210 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 1,210 nTPM
  • tonsil: 1,206 nTPM
  • spleen: 951 nTPM
  • duodenum: 518 nTPM
  • colon: 517 nTPM
  • urinary bladder: 436 nTPM

Single-cell type

  • plasma cells: 7.5 nCPM
  • gastric chief cells: 5.5 nCPM
  • parietal cells: 1.8 nCPM
  • mucous neck cells: 1.6 nCPM
  • foveolar cells: 1.3 nCPM
  • mast cells: 0.9 nCPM

Immune cell

  • memory B-cell: 669 nTPM
  • naive B-cell: 581 nTPM
  • total PBMC: 54 nTPM
  • neutrophil: 1.2 nTPM
  • classical monocyte: 0.7 nTPM
  • MAIT T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 3.4 nTPM
  • choroid plexus: 2 nTPM
  • white matter: 1.8 nTPM
  • amygdala: 1.4 nTPM
  • pons: 1 nTPM
  • basal ganglia: 0.8 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV1-40 as an antibody target. Whether an autoantibody or antibody against IGLV1-40 could matter depends on whether native IGLV1-40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV1-40 is annotated at the cell surface, where native IGLV1-40 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV1-40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV1-40. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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