IGLON5

Protein identityUniProt · HPA

UniProt accession

A6NGN9

Gene

IGLON5

Ensembl

ENSG00000142549

Chromosome

19

Canonical length

336 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted in brain

OverviewNCBI Gene

Predicted to act upstream of or within motor behavior and neuromuscular process controlling balance. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>A6NGN9|IGLON5
     1  MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFNSPAD NYTVCEGDNA TLSCFIDEHV
    61  TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT EVGLGDEGLY TCSFQTRHQP
   121  YTTQVYLIVH VPARIVNISS PVTVNEGGNV NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL
   181  EISDIQRGQA GEYECVTHNG VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA
   241  MAVPPADFQW YKDDRLLSSG TAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS
   301  SASMRLLRPG SLENSAPRPP GLLALLSALG WLWWRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLON5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

49 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGLON5.

Disease | AutoantibodyPubMed

Conditions in which antibodies against IGLON5 are reported. Each links to that disease's full target list.

• Encephalitis 12
• Hashimoto Disease 9
• Autoimmune Diseases of the Nervous System 8

Showing 3 of 5 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for IGLON5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0.4

gnomAD missense Z

1.8

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• motor behavior
• neuromuscular process controlling balance
• neuron recognition

Cellular components

• extracellular region

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• IgLON domain-containing protein
• Immunoglobulin V-set domain
• Immunoglobulin domain

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Repeat
• Secreted
• Signal