IGLL5
Immunoglobulin lambda-like polypeptide 5
Also known as: IGLL5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B9A064
- Gene
- IGLL5
- Ensembl
- ENSG00000254709
- Chromosome
- 22
- Canonical length
- 214 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Canonical amino-acid sequenceUniProt
214 residues, UniProt reviewed canonical sequence.
>B9A064|IGLL5
1 MRPKTGQVGC ETPEELGPGP RQRWPLLLLG LAMVAHGLLR PMVAPQSGDP DPGASVGSSR
61 SSLRSLWGRL LLQPSPQRAD PRCWPRGFWS EPQSLCYVFG TGTKVTVLGQ PKANPTVTLF
121 PPSSEELQAN KATLVCLISD FYPGAVTVAW KADGSPVKAG VETTKPSKQS NNKYAASSYL
181 SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 633 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 633 nTPM
- duodenum: 385 nTPM
- colon: 381 nTPM
- spleen: 310 nTPM
- stomach: 291 nTPM
- lymph node: 290 nTPM
Single-cell type
- plasma cells: 4,049 nCPM
- b-cells: 40 nCPM
- gastric chief cells: 34 nCPM
- foveolar cells: 22 nCPM
- late spermatids: 11 nCPM
- parietal cells: 8.8 nCPM
Immune cell
- naive B-cell: 620 nTPM
- memory B-cell: 518 nTPM
- total PBMC: 68 nTPM
- plasmacytoid DC: 2.5 nTPM
- neutrophil: 1 nTPM
- myeloid DC: 0.8 nTPM
Brain region
- cerebral cortex: 1.3 nTPM
- choroid plexus: 0.6 nTPM
- white matter: 0.6 nTPM
- medulla oblongata: 0.5 nTPM
- spinal cord: 0.5 nTPM
- amygdala: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -6.44
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLL5 as an antibody target. Whether an autoantibody or antibody against IGLL5 could matter depends on whether native IGLL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLL5 is annotated as secreted, so native IGLL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IGLL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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