IGLJ1
Immunoglobulin lambda joining 1
Also known as: LJ01_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MT76
- Gene
- IGLJ1
- Ensembl
- ENSG00000211674
- Chromosome
- 22
- Canonical length
- 42 aa
- Protein class
- Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
42 residues, UniProt reviewed canonical sequence.
>A0A0A0MT76|IGLJ1
1 PSRLLLQPSP QRADPRCWPR GFWSEPQSLC YVFGTGTKVT VLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 94 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 94 nTPM
- lymph node: 50 nTPM
- small intestine: 45 nTPM
- appendix: 42 nTPM
- stomach: 38 nTPM
- tonsil: 38 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 20 nTPM
- naive B-cell: 11 nTPM
- total PBMC: 0.7 nTPM
- plasmacytoid DC: 0.6 nTPM
- classical monocyte: 0.1 nTPM
- eosinophil: 0.1 nTPM
Brain region
- medulla oblongata: 1.1 nTPM
- choroid plexus: 0.9 nTPM
- pons: 0.9 nTPM
- cerebral cortex: 0.7 nTPM
- white matter: 0.7 nTPM
- cerebellum: 0.6 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLJ1 as an antibody target. Whether an autoantibody or antibody against IGLJ1 could matter depends on whether native IGLJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLJ1 is annotated at the cell surface, where native IGLJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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