Seroatlas · Human Serome Atlas

IGLC7

Immunoglobulin lambda constant 7

Also known as: IGLC7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0M8Q6
Gene: IGLC7
Canonical length: 106 aa
Protein class: Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGLC7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>A0M8Q6|IGLC7
     1  GQPKAAPSVT LFPPSSEELQ ANKATLVCLV SDFNPGAVTV AWKADGSPVK VGVETTKPSK
    61  QSNNKYAASS YLSLTPEQWK SHRSYSCRVT HEGSTVEKTV APAECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

stomach: 107 nTPM
tonsil: 98 nTPM
spleen: 95 nTPM
duodenum: 84 nTPM
salivary gland: 67 nTPM
cerebral cortex: 55 nTPM

Single-cell type

plasma cells: 773 nCPM
foveolar cells: 226 nCPM
mucous neck cells: 44 nCPM
gastric chief cells: 24 nCPM
b-cells: 19 nCPM
neuroendocrine cells: 18 nCPM

Immune cell

naive B-cell: 135 nTPM
memory B-cell: 130 nTPM
total PBMC: 26 nTPM
plasmacytoid DC: 0.5 nTPM
basophil: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 3.4 nTPM
cerebral cortex: 3.3 nTPM
white matter: 3.3 nTPM
hypothalamus: 2.5 nTPM
pons: 2.3 nTPM
midbrain: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGLC7.

Disease | ImmuneIEDB

Conditions an epitope on IGLC7 was assayed in.

rheumatoid arthritis B cell

OntologyGO

Biological processes

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLC7 as an antibody target. Whether an autoantibody or antibody against IGLC7 could matter depends on whether native IGLC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLC7 is annotated at the cell surface, where native IGLC7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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