IGLC3
Immunoglobulin lambda constant 3
Also known as: IGLC, IGLC3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DOY3
- Gene
- IGLC3
- Ensembl
- ENSG00000211679
- Chromosome
- 22
- Canonical length
- 106 aa
- Protein class
- Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
106 residues, UniProt reviewed canonical sequence.
>P0DOY3|IGLC3
1 GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK
61 QSNNKYAASS YLSLTPEQWK SHKSYSCQVT HEGSTVEKTV APTECSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 7,643 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 7,643 nTPM
- spleen: 3,955 nTPM
- stomach: 3,885 nTPM
- colon: 3,847 nTPM
- duodenum: 3,809 nTPM
- urinary bladder: 3,497 nTPM
Single-cell type
- plasma cells: 25,605 nCPM
- erythrocytes: 818 nCPM
- foveolar cells: 709 nCPM
- gastric chief cells: 565 nCPM
- b-cells: 359 nCPM
- mucous neck cells: 206 nCPM
Immune cell
- memory B-cell: 7,287 nTPM
- naive B-cell: 6,162 nTPM
- total PBMC: 1,418 nTPM
- plasmacytoid DC: 196 nTPM
- neutrophil: 61 nTPM
- MAIT T-cell: 27 nTPM
Brain region
- cerebral cortex: 13 nTPM
- choroid plexus: 11 nTPM
- medulla oblongata: 9.2 nTPM
- white matter: 8.6 nTPM
- spinal cord: 3.9 nTPM
- hypothalamus: 3.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLC3 as an antibody target. Whether an autoantibody or antibody against IGLC3 could matter depends on whether native IGLC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLC3 is annotated at the cell surface, where native IGLC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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