Seroatlas · Human Serome Atlas

IGLC2

Immunoglobulin lambda constant 2

Also known as: IGLC, IGLC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DOY2
Gene
IGLC2
Ensembl
ENSG00000211677
Chromosome
22
Canonical length
106 aa
Protein class
Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>P0DOY2|IGLC2
     1  GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK
    61  QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
18,672 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 18,672 nTPM
  • stomach: 10,197 nTPM
  • duodenum: 9,137 nTPM
  • colon: 7,679 nTPM
  • spleen: 6,752 nTPM
  • urinary bladder: 6,082 nTPM

Single-cell type

  • plasma cells: 62,189 nCPM
  • parietal cells: 6,278 nCPM
  • gastric chief cells: 3,905 nCPM
  • erythrocytes: 2,865 nCPM
  • foveolar cells: 1,622 nCPM
  • b-cells: 927 nCPM

Immune cell

  • memory B-cell: 11,411 nTPM
  • naive B-cell: 10,729 nTPM
  • total PBMC: 2,391 nTPM
  • plasmacytoid DC: 305 nTPM
  • neutrophil: 119 nTPM
  • classical monocyte: 19 nTPM

Brain region

  • cerebral cortex: 15 nTPM
  • medulla oblongata: 13 nTPM
  • choroid plexus: 12 nTPM
  • white matter: 11 nTPM
  • amygdala: 6.1 nTPM
  • spinal cord: 4.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLC2 as an antibody target. Whether an autoantibody or antibody against IGLC2 could matter depends on whether native IGLC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLC2 is annotated at the cell surface, where native IGLC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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