Seroatlas · Human Serome Atlas

IGLC1

Immunoglobulin lambda constant 1

Also known as: IGLC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG04
Gene: IGLC1
Canonical length: 106 aa
Protein class: Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGLC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>P0CG04|IGLC1
     1  GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK AGVETTKPSK
    61  QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 5,229 nTPM

Expression across tissuesHPA

Tissue

tonsil: 5,229 nTPM
spleen: 3,204 nTPM
duodenum: 3,069 nTPM
colon: 2,843 nTPM
lymph node: 2,227 nTPM
stomach: 2,197 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

naive B-cell: 5,908 nTPM
memory B-cell: 5,791 nTPM
total PBMC: 906 nTPM
classical monocyte: 7.8 nTPM
neutrophil: 7.8 nTPM
myeloid DC: 6 nTPM

Brain region

cerebral cortex: 15 nTPM
choroid plexus: 8.7 nTPM
medulla oblongata: 5.6 nTPM
white matter: 4.9 nTPM
spinal cord: 3.9 nTPM
thalamus: 3.4 nTPM

OntologyGO

Biological processes

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLC1 as an antibody target. Whether an autoantibody or antibody against IGLC1 could matter depends on whether native IGLC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLC1 is annotated at the cell surface, where native IGLC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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