Seroatlas · Human Serome Atlas

IGKV6D-41

Probable non-functional immunoglobulin kappa variable 6D-41

Also known as: KVD41_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0C4DH26
Gene
IGKV6D-41
Ensembl
ENSG00000211626
Chromosome
2
Canonical length
115 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A0C4DH26|IGKV6D-41
     1  MVSPLQFLRL LLLWVPASRG DVVMTQSPAF LSVTPGEKVT ITCQASEGIG NYLYWYQQKP
    61  DQAPKLLIKY ASQSISGVPS RFSGSGSGTD FTFTISSLEA EDAATYYCQQ GNKHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV6D-41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
4.4 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 4.4 nTPM
  • colon: 3.1 nTPM
  • tonsil: 2 nTPM
  • rectum: 1.5 nTPM
  • adrenal gland: 1.3 nTPM
  • appendix: 1.3 nTPM

Single-cell type

  • plasma cells: 0.7 nCPM
  • fallopian tube ciliated cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • naive B-cell: 4.9 nTPM
  • memory B-cell: 3 nTPM
  • total PBMC: 1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV6D-41 as an antibody target. Whether an autoantibody or antibody against IGKV6D-41 could matter depends on whether native IGKV6D-41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV6D-41 is annotated at the cell surface, where native IGKV6D-41 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV6D-41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV6D-41. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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