IGKV6-21
Immunoglobulin kappa variable 6-21
Also known as: A26, IGKV621, KV621_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH24
- Gene
- IGKV6-21
- Ensembl
- ENSG00000211611
- Chromosome
- 2
- Canonical length
- 114 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>A0A0C4DH24|IGKV6-21
1 MLPSQLIGFL LLWVPASRGE IVLTQSPDFQ SVTPKEKVTI TCRASQSIGS SLHWYQQKPD
61 QSPKLLIKYA SQSFSGVPSR FSGSGSGTDF TLTINSLEAE DAATYYCHQS SSLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV6-21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 132 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 132 nTPM
- colon: 91 nTPM
- rectum: 74 nTPM
- spleen: 61 nTPM
- lymph node: 60 nTPM
- salivary gland: 42 nTPM
Single-cell type
- gastric chief cells: 2.2 nCPM
- plasma cells: 1.5 nCPM
- late spermatids: 1.1 nCPM
- foveolar cells: 0.6 nCPM
- salivary myoepithelial cells: 0.3 nCPM
- early spermatids: 0.1 nCPM
Immune cell
- memory B-cell: 29 nTPM
- naive B-cell: 9.9 nTPM
- total PBMC: 3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- medulla oblongata: 0.5 nTPM
- spinal cord: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
- choroid plexus: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- hypothalamus: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV6-21 as an antibody target. Whether an autoantibody or antibody against IGKV6-21 could matter depends on whether native IGKV6-21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV6-21 is annotated at the cell surface, where native IGKV6-21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV6-21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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