IGKV5-2
Immunoglobulin kappa variable 5-2
Also known as: B2, IGKV52, KV502_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P06315
- Gene
- IGKV5-2
- Ensembl
- ENSG00000211599
- Chromosome
- 2
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>P06315|IGKV5-2
1 MGSQVHLLSF LLLWISDTRA ETTLTQSPAF MSATPGDKVN ISCKASQDID DDMNWYQQKP
61 GEAAIFIIQE ATTLVPGIPP RFSGSGYGTD FTLTINNIES EDAAYYFCLQ HDNFPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV5-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 78 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 78 nTPM
- duodenum: 34 nTPM
- spleen: 23 nTPM
- blood vessel: 22 nTPM
- colon: 22 nTPM
- breast: 18 nTPM
Single-cell type
- plasma cells: 2.5 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- memory B-cell: 22 nTPM
- naive B-cell: 17 nTPM
- plasmacytoid DC: 1 nTPM
- total PBMC: 1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV5-2 as an antibody target. Whether an autoantibody or antibody against IGKV5-2 could matter depends on whether native IGKV5-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV5-2 is annotated at the cell surface, where native IGKV5-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV5-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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