Seroatlas · Human Serome Atlas

IGKV4-1

Immunoglobulin kappa variable 4-1

Also known as: B3, IGKV41, KV401_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P06312
Gene
IGKV4-1
Ensembl
ENSG00000211598
Chromosome
2
Canonical length
121 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>P06312|IGKV4-1
     1  MVLQTQVFIS LLLWISGAYG DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA
    61  WYQQKPGQPP KLLIYWASTR ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYST
   121  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV4-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
2,961 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 2,961 nTPM
  • colon: 1,690 nTPM
  • duodenum: 1,664 nTPM
  • rectum: 1,235 nTPM
  • stomach: 1,059 nTPM
  • appendix: 993 nTPM

Single-cell type

  • plasma cells: 893 nCPM
  • gastric chief cells: 22 nCPM
  • foveolar cells: 6.4 nCPM
  • mucous neck cells: 5.5 nCPM
  • b-cells: 4.6 nCPM
  • parietal cells: 3.5 nCPM

Immune cell

  • naive B-cell: 3,093 nTPM
  • memory B-cell: 3,049 nTPM
  • total PBMC: 345 nTPM
  • eosinophil: 5.2 nTPM
  • basophil: 4 nTPM
  • classical monocyte: 3.2 nTPM

Brain region

  • spinal cord: 5.5 nTPM
  • cerebral cortex: 5.3 nTPM
  • pons: 4.9 nTPM
  • choroid plexus: 4.2 nTPM
  • medulla oblongata: 2.7 nTPM
  • white matter: 2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV4-1 as an antibody target. Whether an autoantibody or antibody against IGKV4-1 could matter depends on whether native IGKV4-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV4-1 is annotated at the cell surface, where native IGKV4-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV4-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV4-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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