IGKV3D-7
Immunoglobulin kappa variable 3D-7
Also known as: KVD07_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH55
- Gene
- IGKV3D-7
- Ensembl
- ENSG00000228325
- Chromosome
- 2
- Canonical length
- 119 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>A0A0C4DH55|IGKV3D-7
1 MEPWKPQHSF FFLLLLWLPD TTGEIVMTQS PATLSLSPGE RATLSCRASQ SVSSSYLSWY
61 QQKPGQAPRL LIYGASTRAT GIPARFSGSG SGTDFTLTIS SLQPEDFAVY YCQQDYNLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV3D-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 5.2 nTPM
Expression across tissuesHPA
Tissue
- appendix: 5.2 nTPM
- urinary bladder: 5.1 nTPM
- duodenum: 4.3 nTPM
- small intestine: 4.2 nTPM
- stomach: 4.2 nTPM
- tonsil: 4 nTPM
Single-cell type
- early spermatids: 0.1 nCPM
- plasma cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- naive B-cell: 4.4 nTPM
- memory B-cell: 2.9 nTPM
- total PBMC: 0.6 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- basal ganglia: 0.5 nTPM
- cerebral cortex: 0.5 nTPM
- hypothalamus: 0.4 nTPM
- thalamus: 0.4 nTPM
- amygdala: 0.3 nTPM
- hippocampal formation: 0.3 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV3D-7 as an antibody target. Whether an autoantibody or antibody against IGKV3D-7 could matter depends on whether native IGKV3D-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV3D-7 is annotated at the cell surface, where native IGKV3D-7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV3D-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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