IGKV3D-20
Immunoglobulin kappa variable 3D-20
Also known as: KVD20_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH25
- Gene
- IGKV3D-20
- Ensembl
- ENSG00000211625
- Chromosome
- 2
- Canonical length
- 116 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>A0A0C4DH25|IGKV3D-20
1 METPAQLLFL LLLWLPDTTG EIVLTQSPAT LSLSPGERAT LSCGASQSVS SSYLAWYQQK
61 PGLAPRLLIY DASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV3D-20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 257 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 257 nTPM
- colon: 123 nTPM
- spleen: 86 nTPM
- rectum: 83 nTPM
- stomach: 78 nTPM
- appendix: 77 nTPM
Single-cell type
- plasma cells: 13 nCPM
- gastric chief cells: 4.4 nCPM
- foveolar cells: 2.4 nCPM
- parietal cells: 1.8 nCPM
- macrophages: 0.3 nCPM
- mast cells: 0.3 nCPM
Immune cell
- memory B-cell: 198 nTPM
- naive B-cell: 99 nTPM
- total PBMC: 34 nTPM
- basophil: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- cerebral cortex: 1.1 nTPM
- spinal cord: 0.6 nTPM
- medulla oblongata: 0.3 nTPM
- hypothalamus: 0.2 nTPM
- pons: 0.2 nTPM
- choroid plexus: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV3D-20 as an antibody target. Whether an autoantibody or antibody against IGKV3D-20 could matter depends on whether native IGKV3D-20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV3D-20 is annotated at the cell surface, where native IGKV3D-20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV3D-20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...