IGKV3D-15
Immunoglobulin kappa variable 3D-15
Also known as: KVD15_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A087WSY6
- Gene
- IGKV3D-15
- Ensembl
- ENSG00000224041
- Chromosome
- 2
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A087WSY6|IGKV3D-15
1 MEAPAQLLFL LLLWLPDTTG EIVMTQSPAT LSVSPGERAT LSCRASQSVS SNLAWYQQKP
61 GQAPRLLIYG ASIRATGIPA RFSGSGSGTE FTLTISILQS EDFAVYYCQQ YNNWPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV3D-15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 189 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 189 nTPM
- rectum: 118 nTPM
- colon: 104 nTPM
- appendix: 88 nTPM
- stomach: 82 nTPM
- duodenum: 59 nTPM
Single-cell type
- plasma cells: 2.3 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- memory B-cell: 182 nTPM
- naive B-cell: 157 nTPM
- total PBMC: 28 nTPM
- classical monocyte: 0.8 nTPM
- basophil: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- basal ganglia: 0.7 nTPM
- medulla oblongata: 0.6 nTPM
- choroid plexus: 0.5 nTPM
- spinal cord: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- white matter: 0.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV3D-15 as an antibody target. Whether an autoantibody or antibody against IGKV3D-15 could matter depends on whether native IGKV3D-15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV3D-15 is annotated at the cell surface, where native IGKV3D-15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV3D-15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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