IGKV3-7
Probable non-functional immunoglobulin kappa variable 3-7
Also known as: KV37_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6H7
- Gene
- IGKV3-7
- Ensembl
- ENSG00000243063
- Chromosome
- 2
- Canonical length
- 116 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Cytosol
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>A0A075B6H7|IGKV3-7
1 MEAPAQLLFL LLLWLPDTTR EIVMTQSPPT LSLSPGERVT LSCRASQSVS SSYLTWYQQK
61 PGQAPRLLIY GASTRATSIP ARFSGSGSGT DFTLTISSLQ PEDFAVYYCQ QDYNLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV3-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 21 nTPM
- colon: 17 nTPM
- salivary gland: 15 nTPM
- duodenum: 14 nTPM
- appendix: 14 nTPM
- rectum: 13 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 28 nTPM
- naive B-cell: 25 nTPM
- total PBMC: 4.7 nTPM
- neutrophil: 0.4 nTPM
- T-reg: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV3-7 as an antibody target. Whether an autoantibody or antibody against IGKV3-7 could matter depends on whether native IGKV3-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV3-7 is annotated at the cell surface, where native IGKV3-7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV3-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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