Seroatlas · Human Serome Atlas

IGKV3-11

Immunoglobulin kappa variable 3-11

Also known as: KV311_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04433
Gene
IGKV3-11
Ensembl
ENSG00000241351
Chromosome
2
Canonical length
115 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P04433|IGKV3-11
     1  MEAPAQLLFL LLLWLPDTTG EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP
    61  GQAPRLLIYD ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV3-11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
2,623 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 2,623 nTPM
  • urinary bladder: 1,711 nTPM
  • colon: 1,282 nTPM
  • spleen: 1,053 nTPM
  • rectum: 1,020 nTPM
  • stomach: 741 nTPM

Single-cell type

  • plasma cells: 19 nCPM
  • gastric chief cells: 6.6 nCPM
  • parietal cells: 5.3 nCPM
  • mucous neck cells: 3.1 nCPM
  • foveolar cells: 2.6 nCPM
  • b-cells: 0.6 nCPM

Immune cell

  • memory B-cell: 1,738 nTPM
  • naive B-cell: 1,409 nTPM
  • total PBMC: 187 nTPM
  • neutrophil: 5.4 nTPM
  • gdT-cell: 2 nTPM
  • basophil: 1.9 nTPM

Brain region

  • spinal cord: 34 nTPM
  • cerebral cortex: 2.3 nTPM
  • pons: 1.4 nTPM
  • white matter: 1.4 nTPM
  • midbrain: 1 nTPM
  • medulla oblongata: 0.9 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV3-11 as an antibody target. Whether an autoantibody or antibody against IGKV3-11 could matter depends on whether native IGKV3-11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV3-11 is annotated at the cell surface, where native IGKV3-11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV3-11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV3-11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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