Seroatlas · Human Serome Atlas

IGKV2D-40

Immunoglobulin kappa variable 2D-40

Also known as: KVD40_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01614
Gene
IGKV2D-40
Ensembl
ENSG00000251039
Chromosome
2
Canonical length
121 aa
Protein class
Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>P01614|IGKV2D-40
     1  MRLPAQLLGL LMLWVPGSSE DIVMTQTPLS LPVTPGEPAS ISCRSSQSLL DSDDGNTYLD
    61  WYLQKPGQSP QLLIYTLSYR ASGVPDRFSG SGSGTDFTLK ISRVEAEDVG VYYCMQRIEF
   121  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV2D-40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 109 nTPM
  • lymph node: 61 nTPM
  • spleen: 41 nTPM
  • stomach: 25 nTPM
  • salivary gland: 25 nTPM
  • small intestine: 24 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • memory B-cell: 123 nTPM
  • naive B-cell: 95 nTPM
  • total PBMC: 5.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV2D-40 as an antibody target. Whether an autoantibody or antibody against IGKV2D-40 could matter depends on whether native IGKV2D-40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV2D-40 is annotated at the cell surface, where native IGKV2D-40 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV2D-40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV2D-40. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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