IGKV2D-30
Immunoglobulin kappa variable 2D-30
Also known as: KVD30_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6S6
- Gene
- IGKV2D-30
- Ensembl
- ENSG00000239571
- Chromosome
- 2
- Canonical length
- 120 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
120 residues, UniProt reviewed canonical sequence.
>A0A075B6S6|IGKV2D-30
1 MRLPAQLLGL LMLWVPGSSG DVVMTQSPLS LPVTLGQPAS ISCRSSQSLV YSDGNTYLNW
61 FQQRPGQSPR RLIYKVSNWD SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV2D-30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 31 nTPM
- spleen: 27 nTPM
- stomach: 21 nTPM
- colon: 14 nTPM
- salivary gland: 12 nTPM
- duodenum: 11 nTPM
Single-cell type
- plasma cells: 4.1 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- naive B-cell: 164 nTPM
- memory B-cell: 125 nTPM
- total PBMC: 19 nTPM
- neutrophil: 0.3 nTPM
- eosinophil: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
Brain region
- hippocampal formation: 0.3 nTPM
- hypothalamus: 0.2 nTPM
- pons: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV2D-30 as an antibody target. Whether an autoantibody or antibody against IGKV2D-30 could matter depends on whether native IGKV2D-30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV2D-30 is annotated at the cell surface, where native IGKV2D-30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV2D-30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...