IGKV2D-29
Immunoglobulin kappa variable 2D-29
Also known as: KVD29_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6S2
- Gene
- IGKV2D-29
- Ensembl
- ENSG00000243264
- Chromosome
- 2
- Canonical length
- 120 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
120 residues, UniProt reviewed canonical sequence.
>A0A075B6S2|IGKV2D-29
1 MRLPAQLLGL LMLWIPGSSA DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL HSDGKTYLYW
61 YLQKPGQPPQ LLIYEVSNRF SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQSIQLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV2D-29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 433 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 433 nTPM
- colon: 235 nTPM
- spleen: 173 nTPM
- lymph node: 131 nTPM
- stomach: 116 nTPM
- rectum: 104 nTPM
Single-cell type
- plasma cells: 35 nCPM
- b-cells: 1.2 nCPM
- gastric chief cells: 1.1 nCPM
- mucous neck cells: 0.8 nCPM
- foveolar cells: 0.6 nCPM
- fibroblasts: 0.1 nCPM
Immune cell
- naive B-cell: 488 nTPM
- memory B-cell: 357 nTPM
- total PBMC: 42 nTPM
- neutrophil: 1.6 nTPM
- myeloid DC: 0.6 nTPM
- classical monocyte: 0.4 nTPM
Brain region
- cerebral cortex: 1.9 nTPM
- choroid plexus: 1.5 nTPM
- spinal cord: 0.7 nTPM
- medulla oblongata: 0.5 nTPM
- pons: 0.5 nTPM
- white matter: 0.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV2D-29 as an antibody target. Whether an autoantibody or antibody against IGKV2D-29 could matter depends on whether native IGKV2D-29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV2D-29 is annotated at the cell surface, where native IGKV2D-29 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV2D-29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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