IGKV2-30
Immunoglobulin kappa variable 2-30
Also known as: KV230_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P06310
- Gene
- IGKV2-30
- Ensembl
- ENSG00000243238
- Chromosome
- 2
- Canonical length
- 120 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
120 residues, UniProt reviewed canonical sequence.
>P06310|IGKV2-30
1 MRLPAQLLGL LMLWVPGSSG DVVMTQSPLS LPVTLGQPAS ISCRSSQSLV YSDGNTYLNW
61 FQQRPGQSPR RLIYKVSNRD SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV2-30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 627 nTPM
Expression across tissuesHPA
Tissue
- spleen: 627 nTPM
- colon: 590 nTPM
- tonsil: 560 nTPM
- duodenum: 370 nTPM
- stomach: 304 nTPM
- rectum: 303 nTPM
Single-cell type
- b-cells: 0.5 nCPM
- microglia: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- memory B-cell: 562 nTPM
- naive B-cell: 326 nTPM
- total PBMC: 53 nTPM
- neutrophil: 1.4 nTPM
- plasmacytoid DC: 0.7 nTPM
- basophil: 0.5 nTPM
Brain region
- medulla oblongata: 2.6 nTPM
- cerebral cortex: 1.8 nTPM
- white matter: 1.8 nTPM
- choroid plexus: 1.2 nTPM
- spinal cord: 0.9 nTPM
- basal ganglia: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV2-30 as an antibody target. Whether an autoantibody or antibody against IGKV2-30 could matter depends on whether native IGKV2-30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV2-30 is annotated at the cell surface, where native IGKV2-30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV2-30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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