Seroatlas · Human Serome Atlas

IGKV2-29

Immunoglobulin kappa variable 2-29

Also known as: KV229_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2NJV5
Gene: IGKV2-29
Canonical length: 120 aa

OverviewNCBI Gene

No narrative summary is available for IGKV2-29 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>A2NJV5|IGKV2-29
     1  MRLPAQLLGL LMLWIPGSSA DIVMTQTPLS LSVTPGQPAS ISCKSSQSLL HSDGKTYLYW
    61  YLQKPGQSPQ LLIYEVSSRF SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGIHLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV2-29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV2-29 as an antibody target. Whether an autoantibody or antibody against IGKV2-29 could matter depends on whether native IGKV2-29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV2-29 is annotated at the cell surface, where native IGKV2-29 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV2-29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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