Seroatlas · Human Serome Atlas

IGKV2-28

Immunoglobulin kappa variable 2-28

Also known as: KV228_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6P5
Gene
IGKV2-28
Ensembl
ENSG00000244116
Chromosome
2
Canonical length
120 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>A0A075B6P5|IGKV2-28
     1  MRLPAQLLGL LMLWVSGSSG DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW
    61  YLQKPGQSPQ LLIYLGSNRA SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQALQTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV2-28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,670 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,670 nTPM
  • spleen: 1,227 nTPM
  • colon: 1,022 nTPM
  • duodenum: 752 nTPM
  • salivary gland: 707 nTPM
  • rectum: 678 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • naive B-cell: 41 nTPM
  • memory B-cell: 2.8 nTPM
  • neutrophil: 1 nTPM
  • basophil: 0.7 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • classical monocyte: 0.4 nTPM

Brain region

  • cerebral cortex: 1.8 nTPM
  • choroid plexus: 1.8 nTPM
  • midbrain: 1.6 nTPM
  • spinal cord: 1.4 nTPM
  • white matter: 1.4 nTPM
  • medulla oblongata: 1.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV2-28 as an antibody target. Whether an autoantibody or antibody against IGKV2-28 could matter depends on whether native IGKV2-28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV2-28 is annotated at the cell surface, where native IGKV2-28 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV2-28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV2-28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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