IGKV1D-37
Probable non-functional immunoglobulinn kappa variable 1D-37
Also known as: IGKV1D37, KVD37_HUMAN, O4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DSN7
- Gene
- IGKV1D-37
- Ensembl
- ENSG00000250036
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P0DSN7|IGKV1D-37
1 MDMRVPAQLL GLLLLWVPGA RCDIQLTQSP SSLSASVGDR VTITCRVSQG ISSYLNWYRQ
61 KPGKVPKLLI YSASNLQSGV PSRFSGSGSG TDFTLTISSL QPEDVATYYG QRTYNAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1D-37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- urinary bladder: 19 nTPM
- stomach: 14 nTPM
- duodenum: 12 nTPM
- colon: 8.1 nTPM
- salivary gland: 6.7 nTPM
- spleen: 6.1 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- naive B-cell: 29 nTPM
- memory B-cell: 14 nTPM
- total PBMC: 1.5 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- hippocampal formation: 0.9 nTPM
- midbrain: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1D-37 as an antibody target. Whether an autoantibody or antibody against IGKV1D-37 could matter depends on whether native IGKV1D-37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1D-37 is annotated at the cell surface, where native IGKV1D-37 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1D-37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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