IGKV1D-33
Immunoglobulin kappa variable 1D-33
Also known as: KVD33_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01593
- Gene
- IGKV1D-33
- Ensembl
- ENSG00000239975
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01593|IGKV1D-33
1 MDMRVPAQLL GLLLLWLSGA RCDIQMTQSP SSLSASVGDR VTITCQASQD ISNYLNWYQQ
61 KPGKAPKLLI YDASNLETGV PSRFSGSGSG TDFTFTISSL QPEDIATYYC QQYDNLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1D-33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 63 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 63 nTPM
- spleen: 61 nTPM
- colon: 34 nTPM
- stomach: 22 nTPM
- small intestine: 18 nTPM
- lung: 16 nTPM
Single-cell type
- plasma cells: 0.2 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- memory B-cell: 2.7 nTPM
- naive B-cell: 0.6 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- hippocampal formation: 0.4 nTPM
- cerebral cortex: 0.3 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1D-33 as an antibody target. Whether an autoantibody or antibody against IGKV1D-33 could matter depends on whether native IGKV1D-33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1D-33 is annotated at the cell surface, where native IGKV1D-33 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1D-33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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