IGKV1D-17
Immunoglobulin kappa variable 1D-17
Also known as: KVD17_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6S4
- Gene
- IGKV1D-17
- Ensembl
- ENSG00000242766
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>A0A075B6S4|IGKV1D-17
1 MDMRVPAQLL GLLLLWFPGA RCNIQMTQSP SAMSASVGDR VTITCRARQG ISNYLAWFQQ
61 KPGKVPKHLI YAASSLQSGV PSRFSGSGSG TEFTLTISSL QPEDFATYYC LQHNSYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1D-17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- spleen: 11 nTPM
- colon: 6.7 nTPM
- salivary gland: 5.4 nTPM
- appendix: 4.8 nTPM
- small intestine: 4.5 nTPM
- tonsil: 4.2 nTPM
Single-cell type
- plasma cells: 16 nCPM
- foveolar cells: 0.3 nCPM
- monocytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- memory B-cell: 7.7 nTPM
- naive B-cell: 4.1 nTPM
- total PBMC: 0.9 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- choroid plexus: 2.6 nTPM
- pons: 2 nTPM
- white matter: 1.5 nTPM
- cerebral cortex: 1.4 nTPM
- hypothalamus: 1.4 nTPM
- medulla oblongata: 1.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1D-17 as an antibody target. Whether an autoantibody or antibody against IGKV1D-17 could matter depends on whether native IGKV1D-17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1D-17 is annotated at the cell surface, where native IGKV1D-17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1D-17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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