IGKV1D-12
Immunoglobulin kappa variable 1D-12
Also known as: KVD12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01611
- Gene
- IGKV1D-12
- Ensembl
- ENSG00000278857
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01611|IGKV1D-12
1 MDMMVPAQLL GLLLLWFPGS RCDIQMTQSP SSVSASVGDR VTITCRASQG ISSWLAWYQQ
61 KPGKAPKLLI YAASSLQSGV PSRFSGSGSG TDFTLTISSL QPEDFATYYC QQANSFPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1D-12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- spleen: 45 nTPM
- salivary gland: 34 nTPM
- colon: 27 nTPM
- small intestine: 21 nTPM
- lymph node: 12 nTPM
- lung: 11 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 13 nTPM
- naive B-cell: 12 nTPM
- total PBMC: 3.8 nTPM
- neutrophil: 0.3 nTPM
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- medulla oblongata: 0.2 nTPM
- pons: 0.2 nTPM
- white matter: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- midbrain: 0.1 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1D-12 as an antibody target. Whether an autoantibody or antibody against IGKV1D-12 could matter depends on whether native IGKV1D-12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1D-12 is annotated at the cell surface, where native IGKV1D-12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1D-12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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