IGKV1-8
Immunoglobulin kappa variable 1-8
Also known as: IGKV18, KV108_HUMAN, L9
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH67
- Gene
- IGKV1-8
- Ensembl
- ENSG00000240671
- Chromosome
- 2
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A0C4DH67|IGKV1-8
1 MRVPAQLLGL LLLWLPGARC AIRMTQSPSS FSASTGDRVT ITCRASQGIS SYLAWYQQKP
61 GKAPKLLIYA ASTLQSGVPS RFSGSGSGTD FTLTISCLQS EDFATYYCQQ YYSYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 51 nTPM
- spleen: 47 nTPM
- urinary bladder: 39 nTPM
- colon: 28 nTPM
- salivary gland: 21 nTPM
- rectum: 18 nTPM
Single-cell type
- plasma cells: 5.1 nCPM
- mast cells: 0.3 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- naive B-cell: 137 nTPM
- memory B-cell: 132 nTPM
- total PBMC: 12 nTPM
- memory CD8 T-cell: 0.4 nTPM
- basophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1-8 as an antibody target. Whether an autoantibody or antibody against IGKV1-8 could matter depends on whether native IGKV1-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1-8 is annotated at the cell surface, where native IGKV1-8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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