IGKV1-6
Immunoglobulin kappa variable 1-6
Also known as: KV106_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH72
- Gene
- IGKV1-6
- Ensembl
- ENSG00000239855
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>A0A0C4DH72|IGKV1-6
1 MDMRVPAQLL GLLLLWLPGA RCAIQMTQSP SSLSASVGDR VTITCRASQG IRNDLGWYQQ
61 KPGKAPKLLI YAASSLQSGV PSRFSGSGSG TDFTLTISSL QPEDFATYYC LQDYNYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1-6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 565 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 565 nTPM
- spleen: 199 nTPM
- colon: 145 nTPM
- rectum: 136 nTPM
- urinary bladder: 136 nTPM
- stomach: 123 nTPM
Single-cell type
- plasma cells: 31 nCPM
- innate lymphoid cells: 0.4 nCPM
- foveolar cells: 0.3 nCPM
- neutrophils: 0.3 nCPM
- b-cells: 0.1 nCPM
- late primary spermatocytes: 0.1 nCPM
Immune cell
- memory B-cell: 124 nTPM
- naive B-cell: 86 nTPM
- total PBMC: 14 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- cerebral cortex: 0.7 nTPM
- spinal cord: 0.4 nTPM
- white matter: 0.3 nTPM
- choroid plexus: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1-6 as an antibody target. Whether an autoantibody or antibody against IGKV1-6 could matter depends on whether native IGKV1-6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1-6 is annotated at the cell surface, where native IGKV1-6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1-6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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