Seroatlas · Human Serome Atlas

IGKV1-5

Immunoglobulin kappa variable 1-5

Also known as: KV105_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01602
Gene
IGKV1-5
Ensembl
ENSG00000243466
Chromosome
2
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P01602|IGKV1-5
     1  MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS ISSWLAWYQQ
    61  KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL QPDDFATYYC QQYNSYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKV1-5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,363 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,363 nTPM
  • urinary bladder: 887 nTPM
  • spleen: 863 nTPM
  • colon: 728 nTPM
  • rectum: 697 nTPM
  • appendix: 603 nTPM

Single-cell type

  • plasma cells: 164 nCPM
  • gastric chief cells: 15 nCPM
  • parietal cells: 11 nCPM
  • foveolar cells: 5.1 nCPM
  • mucous neck cells: 2.8 nCPM
  • mast cells: 1.4 nCPM

Immune cell

  • naive B-cell: 867 nTPM
  • memory B-cell: 863 nTPM
  • total PBMC: 114 nTPM
  • memory CD4 T-cell: 2.3 nTPM
  • neutrophil: 1.4 nTPM
  • eosinophil: 1.3 nTPM

Brain region

  • spinal cord: 2.3 nTPM
  • cerebral cortex: 2 nTPM
  • medulla oblongata: 1.5 nTPM
  • choroid plexus: 1 nTPM
  • hypothalamus: 0.8 nTPM
  • white matter: 0.8 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKV1-5 as an antibody target. Whether an autoantibody or antibody against IGKV1-5 could matter depends on whether native IGKV1-5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKV1-5 is annotated at the cell surface, where native IGKV1-5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKV1-5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKV1-5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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