IGKV1-27
Immunoglobulin kappa variable 1-27
Also known as: A20, IGKV127, KV127_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6S5
- Gene
- IGKV1-27
- Ensembl
- ENSG00000244575
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>A0A075B6S5|IGKV1-27
1 MDMRVPAQLL GLLLLWLPDT RCDIQMTQSP SSLSASVGDR VTITCRASQG ISNYLAWYQQ
61 KPGKVPKLLI YAASTLQSGV PSRFSGSGSG TDFTLTISSL QPEDVATYYC QKYNSAPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1-27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 324 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 324 nTPM
- spleen: 264 nTPM
- colon: 251 nTPM
- rectum: 198 nTPM
- small intestine: 188 nTPM
- duodenum: 172 nTPM
Single-cell type
- plasma cells: 11 nCPM
- parietal cells: 3.5 nCPM
- gastric chief cells: 1.1 nCPM
- foveolar cells: 0.3 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- naive B-cell: 187 nTPM
- memory B-cell: 154 nTPM
- total PBMC: 16 nTPM
- basophil: 0.2 nTPM
- classical monocyte: 0.2 nTPM
- eosinophil: 0.1 nTPM
Brain region
- medulla oblongata: 1.5 nTPM
- cerebral cortex: 0.8 nTPM
- midbrain: 0.7 nTPM
- spinal cord: 0.5 nTPM
- white matter: 0.4 nTPM
- hypothalamus: 0.3 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1-27 as an antibody target. Whether an autoantibody or antibody against IGKV1-27 could matter depends on whether native IGKV1-27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1-27 is annotated at the cell surface, where native IGKV1-27 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1-27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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