IGKV1-17
Immunoglobulin kappa variable 1-17
Also known as: A30, IGKV117, KV117_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01599
- Gene
- IGKV1-17
- Ensembl
- ENSG00000240382
- Chromosome
- 2
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01599|IGKV1-17
1 MDMRVPAQLL GLLLLWFPGA RCDIQMTQSP SSLSASVGDR VTITCRASQG IRNDLGWYQQ
61 KPGKAPKRLI YAASSLQSGV PSRFSGSGSG TEFTLTISSL QPEDFATYYC LQHNSYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKV1-17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 423 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 423 nTPM
- rectum: 350 nTPM
- colon: 335 nTPM
- spleen: 293 nTPM
- duodenum: 276 nTPM
- appendix: 173 nTPM
Single-cell type
- plasma cells: 9.3 nCPM
- parietal cells: 3.5 nCPM
- gastric chief cells: 2.2 nCPM
- foveolar cells: 0.6 nCPM
- neuroendocrine cells: 0.5 nCPM
- b-cells: 0.3 nCPM
Immune cell
- memory B-cell: 106 nTPM
- naive B-cell: 83 nTPM
- total PBMC: 13 nTPM
- NK-cell: 0.2 nTPM
- basophil: 0.1 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- medulla oblongata: 1.2 nTPM
- choroid plexus: 0.8 nTPM
- cerebral cortex: 0.7 nTPM
- thalamus: 0.4 nTPM
- basal ganglia: 0.3 nTPM
- pons: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKV1-17 as an antibody target. Whether an autoantibody or antibody against IGKV1-17 could matter depends on whether native IGKV1-17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKV1-17 is annotated at the cell surface, where native IGKV1-17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKV1-17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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