IGKJ1
Immunoglobulin kappa joining 1
Also known as: J1, KJ01_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MT89
- Gene
- IGKJ1
- Ensembl
- ENSG00000211597
- Chromosome
- 2
- Canonical length
- 12 aa
- Protein class
- Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
12 residues, UniProt reviewed canonical sequence.
>A0A0A0MT89|IGKJ1
1 WTFGQGTKVE IKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGKJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 3,132 nTPM
Expression across tissuesHPA
Tissue
- appendix: 3,132 nTPM
- duodenum: 2,904 nTPM
- tonsil: 2,338 nTPM
- stomach: 2,293 nTPM
- small intestine: 2,109 nTPM
- colon: 1,809 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 38,195 nTPM
- naive B-cell: 32,247 nTPM
- plasmacytoid DC: 14,819 nTPM
- total PBMC: 3,899 nTPM
- neutrophil: 68 nTPM
- myeloid DC: 57 nTPM
Brain region
- choroid plexus: 11 nTPM
- cerebral cortex: 10 nTPM
- medulla oblongata: 6 nTPM
- spinal cord: 5.7 nTPM
- white matter: 4.9 nTPM
- hippocampal formation: 4.8 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGKJ1 as an antibody target. Whether an autoantibody or antibody against IGKJ1 could matter depends on whether native IGKJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGKJ1 is annotated at the cell surface, where native IGKJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGKJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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