Seroatlas · Human Serome Atlas

IGIP

IgA-inducing protein homolog

Also known as: C5orf53, IGIP_HUMAN, LOC492311

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJ69
Gene
IGIP
Ensembl
ENSG00000182700
Chromosome
5
Canonical length
53 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

53 residues, UniProt reviewed canonical sequence.

>A6NJ69|IGIP
     1  MCSYYHMKKR SVSGCNITIF AVMFSHLSAG KSPCGNQANV LCISRLEFVQ YQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 44 nTPM
  • midbrain: 42 nTPM
  • cerebellum: 39 nTPM
  • hypothalamus: 38 nTPM
  • amygdala: 37 nTPM
  • hippocampal formation: 36 nTPM

Single-cell type

  • lactotrophs: 34 nCPM
  • thyrotrophs: 33 nCPM
  • somatotrophs: 29 nCPM
  • corticotrophs: 29 nCPM
  • brain inhibitory neurons: 22 nCPM
  • gonadotrophs: 22 nCPM

Immune cell

  • naive CD4 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • spinal cord: 56 nTPM
  • thalamus: 55 nTPM
  • midbrain: 52 nTPM
  • pons: 50 nTPM
  • amygdala: 50 nTPM
  • medulla oblongata: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0.38
gnomAD missense Z
0.1
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • IgA-inducing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGIP as an antibody target. Whether an autoantibody or antibody against IGIP could matter depends on whether native IGIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGIP is annotated as secreted, so native IGIP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IGIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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