Seroatlas · Human Serome Atlas

IGHV8-51-1

Probable non-functional immunoglobulin heavy variable 8-51-1

Also known as: HV511_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DTE2
Gene
IGHV8-51-1
Canonical length
115 aa
Protein class
Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGHV8-51-1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P0DTE2|IGHV8-51-1
     1  MLVCVLLYSF RLFGIQGEAQ LTESGGDLVH LEGPLRLSCA ASWFTFSIYE IHWVCQASGK
    61  GLEWVAVIWR GESHQYNADY VRGRLTTSRD NTKYMLYMQM ISLRTQNMAA FNCAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV8-51-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 1.4 nTPM
  • bone marrow: 0.2 nTPM
  • lymph node: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • memory B-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV8-51-1 as an antibody target. Whether an autoantibody or antibody against IGHV8-51-1 could matter depends on whether native IGHV8-51-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV8-51-1 is annotated at the cell surface, where native IGHV8-51-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV8-51-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV8-51-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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