Seroatlas · Human Serome Atlas

IGHV6-1

Immunoglobulin heavy variable 6-1

Also known as: HV601_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0B4J1U7
Gene: IGHV6-1
Ensembl: ENSG00000211933
Chromosome: 14
Canonical length: 121 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>A0A0B4J1U7|IGHV6-1
     1  MSVSFLIFLP VLGLPWGVLS QVQLQQSGPG LVKPSQTLSL TCAISGDSVS SNSAAWNWIR
    61  QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR ITINPDTSKN QFSLQLNSVT PEDTAVYYCA
   121  R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV6-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 415 nTPM

Expression across tissuesHPA

Tissue

colon: 415 nTPM
spleen: 147 nTPM
salivary gland: 55 nTPM
small intestine: 39 nTPM
stomach: 21 nTPM
esophagus: 17 nTPM

Single-cell type

plasma cells: 8.2 nCPM
gastric chief cells: 1.1 nCPM
mucous neck cells: 0.8 nCPM
mast cells: 0.6 nCPM
b-cells: 0.2 nCPM
erythrocytes: 0.2 nCPM

Immune cell

naive B-cell: 20 nTPM
memory B-cell: 3.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

amygdala: 0.5 nTPM
choroid plexus: 0.5 nTPM
medulla oblongata: 0.5 nTPM
spinal cord: 0.5 nTPM
cerebral cortex: 0.4 nTPM
thalamus: 0.4 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV6-1 as an antibody target. Whether an autoantibody or antibody against IGHV6-1 could matter depends on whether native IGHV6-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV6-1 is annotated at the cell surface, where native IGHV6-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV6-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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